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KMID : 0861020120270030075
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.75 ~ p.82
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Comparitive study on anti-asthmatic activities of Patrinia scabiosaefolia Fischer ex Link and Patrinia villosa Jussieu in a mouse model of asthma
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Cha Jong-Tae
Lee Jang-Cheon
Lee Young-Cheol
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Abstract
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Objective: In the present study, we investigated the pharmacological profile of the aqueous extract of Patrinia
scabiosaefolia Fischer ex Link (EPS) and Patrinia villosa Jussieu (EPV) for its anti-asthmatic activities. The
purpose of this study is to ascertain if EPS result in better anti-asthmatic activities and functional outcome as
compared with EPV.
Methods: In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally,
intraperitoneally, and by aerosol allergen challenges. We investigated the effect of EPS, EPV on the recruitment
of pulmonary inflammatory cells, various immune cell phenotypes, Th1/Th2 cytokine gene expression and
production and histamine production in serum.
Results: In BALB/c mice, we found that EPV-treated groups had more effectively suppressed inflammatory cell
infiltration of lung and BALF, B220+IgE+, CD11b+Gr-1+ cell population in lung and these occurred by
suppressing the gene expression of IL-4, IL-5 and IL-4 cytokine production in BALF and serum.
Conclusions: These results suggest that EPV may play an important role in the control of anti-asthmatic
activities by down-regulation of Th2 cytokine (especially IL-4, IL-5). In general, EPV has shown a better
anti-asthmatic activities compared to EPS.
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KEYWORD
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Patrinia scabiosaefolia Fischer ex Link, EPS, Patrinia villosa Jussieu, EPV, asthma, IL-4, IL-5
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